The effect of chloroacetophenone on chick embryos cultured in vitro.

INTRODUCTION BRACHET'S (1950) strong emphasis on the role of—SH-containing proteins in the process of induction has stimulated a study of the interference in the normal process of morphogenesis of chick embryos by chloroacetophenone, which has been described by Beatty (1951) as a specific and irreversible —SH inhibitor. He studied the effect of chloroacetophenone on the development of embryos of Rana and Triturus employing different concentrations. Deuchar (1957) also studied the action of the same chemical on the embryos of Xenopus laevis and has recorded abnormalities mainly in the brain and the eye. In the present work oj-chloroacetophenone (CAP) commercially known as phenacyl chloride (OJ—C6H5. CO. CH2C1) was employed. The sample used was a B.D.H. product.